There is restricted VH and VL combination and usage among the antibodies. Typically, the antibodies bind gluten peptides related to T-cell epitopes and many have higher reactivity to deamidated peptides. Monoclonal antibodies were expression cloned from single PCs of patients either isolated from cultures with reactivity to complex deamidated gluten antigen or by sorting with gluten peptide tetramers. Here we report that gluten-specific IgA of lesion-resident PCs share this feature. TG2-specific immunoglobulin A (IgA) of plasma cells (PCs) from CD lesions have limited somatic hypermutation (SHM). ![]() ![]() ![]() Coeliac disease (CD), an enteropathy caused by cereal gluten ingestion, is characterized by CD4 + T cells recognizing deamidated gluten and by antibodies reactive to gluten or the self-antigen transglutaminase 2 (TG2).
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